DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function
Identifieur interne : 001695 ( Main/Exploration ); précédent : 001694; suivant : 001696DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function
Auteurs : Min Shi [États-Unis] ; Amy Furay [États-Unis] ; Vesna Sossi ; Jan O. Aasly [Norvège] ; Jeff Armaly [États-Unis] ; Yu Wang [États-Unis, République populaire de Chine] ; Zbigniew K. Wszolek [États-Unis] ; Ryan J. Uitti [États-Unis] ; Kazuko Hasegawa [Japon] ; Teruo Yokoyama [Japon] ; Cyrus P. Zabetian [États-Unis] ; James B. Leverenz [États-Unis] ; A. Jon Stoessl ; Jing Zhang [États-Unis]Source :
- Neurobiology of Aging [ 0197-4580 ] ; 2011.
Abstract
Previous studies demonstrated decreased levels of DJ-1 and α-synuclein (αSYN) in human cerebrospinal fluid (CSF) in patients with Parkinson’s disease (PD), but neither marker correlated with PD severity, raising the possibility that they may be excellent progression markers during early or preclinical phases of PD. Individuals carrying the leucine-rich repeat kinase 2 (LRRK2) gene mutation are at increased risk for PD, and the phenotype of LRRK2 patients is almost identical to sporadic PD. To determine whether dopaminergic dysfunction in the basal ganglia, as determined by positron emission tomography (PET) scans, correlates with CSF levels of DJ-1 and αSYN during preclinical stages, Luminex assays were used to analyze CSF samples from asymptomatic LRRK2 mutation carriers, along with carriers who presented with a clinical diagnosis of PD. The data revealed no statistically significant relationship between PET scan evidence of loss of striatal dopaminergic function and the CSF biomarkers DJ-1 and αSYN, except for a weak correlation between DJ-1 and MP binding, suggesting that the use of these potential biomarkers on their own to screen LRRK2 gene mutation carriers for PD is not appropriate.
Url:
DOI: 10.1016/j.neurobiolaging.2011.09.015
PubMed: 22019052
PubMed Central: 3279603
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000474
- to stream Pmc, to step Curation: 000474
- to stream Pmc, to step Checkpoint: 000971
- to stream Ncbi, to step Merge: 000F86
- to stream Ncbi, to step Curation: 000F86
- to stream Ncbi, to step Checkpoint: 000F86
- to stream Main, to step Merge: 001767
- to stream Main, to step Curation: 001695
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function</title><author><name sortKey="Shi, Min" sort="Shi, Min" uniqKey="Shi M" first="Min" last="Shi">Min Shi</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Furay, Amy" sort="Furay, Amy" uniqKey="Furay A" first="Amy" last="Furay">Amy Furay</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name><affiliation><nlm:aff id="A2">Department of Physics & Astronomy, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Purdy Pavilion, Vancouver, BC V6T2B5 Canada</nlm:aff><wicri:noCountry code="subfield">BC V6T2B5 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Neurology, St. Olavs Hospital, Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St. Olavs Hospital, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Armaly, Jeff" sort="Armaly, Jeff" uniqKey="Armaly J" first="Jeff" last="Armaly">Jeff Armaly</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan</wicri:regionArea><wicri:noRegion>Wuhan</wicri:noRegion></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic Florida, Jacksonville, FL</wicri:regionArea><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic Florida, Jacksonville, FL</wicri:regionArea><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Yokoyama, Teruo" sort="Yokoyama, Teruo" uniqKey="Yokoyama T" first="Teruo" last="Yokoyama">Teruo Yokoyama</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name><affiliation wicri:level="1"><nlm:aff id="A7">Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name><affiliation wicri:level="1"><nlm:aff id="A8">Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation><nlm:aff id="A12">Pacific Parkinson’s Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC V6T2B5 Canada</nlm:aff><wicri:noCountry code="subfield">BC V6T2B5 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22019052</idno><idno type="pmc">3279603</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279603</idno><idno type="RBID">PMC:3279603</idno><idno type="doi">10.1016/j.neurobiolaging.2011.09.015</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000474</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000474</idno><idno type="wicri:Area/Pmc/Curation">000474</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000474</idno><idno type="wicri:Area/Pmc/Checkpoint">000971</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000971</idno><idno type="wicri:Area/Ncbi/Merge">000F86</idno><idno type="wicri:Area/Ncbi/Curation">000F86</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F86</idno><idno type="wicri:doubleKey">0197-4580:2011:Shi M:dj:and:syn</idno><idno type="wicri:Area/Main/Merge">001767</idno><idno type="wicri:Area/Main/Curation">001695</idno><idno type="wicri:Area/Main/Exploration">001695</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function</title><author><name sortKey="Shi, Min" sort="Shi, Min" uniqKey="Shi M" first="Min" last="Shi">Min Shi</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Furay, Amy" sort="Furay, Amy" uniqKey="Furay A" first="Amy" last="Furay">Amy Furay</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name><affiliation><nlm:aff id="A2">Department of Physics & Astronomy, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Purdy Pavilion, Vancouver, BC V6T2B5 Canada</nlm:aff><wicri:noCountry code="subfield">BC V6T2B5 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Neurology, St. Olavs Hospital, Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St. Olavs Hospital, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Armaly, Jeff" sort="Armaly, Jeff" uniqKey="Armaly J" first="Jeff" last="Armaly">Jeff Armaly</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan</wicri:regionArea><wicri:noRegion>Wuhan</wicri:noRegion></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic Florida, Jacksonville, FL</wicri:regionArea><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic Florida, Jacksonville, FL</wicri:regionArea><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Yokoyama, Teruo" sort="Yokoyama, Teruo" uniqKey="Yokoyama T" first="Teruo" last="Yokoyama">Teruo Yokoyama</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, National Hospital Organization, Sagamihara National Hospital, Kanagawa</wicri:regionArea><wicri:noRegion>Kanagawa</wicri:noRegion></affiliation></author><author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name><affiliation wicri:level="1"><nlm:aff id="A7">Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name><affiliation wicri:level="1"><nlm:aff id="A8">Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson’s Disease Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation><nlm:aff id="A12">Pacific Parkinson’s Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC V6T2B5 Canada</nlm:aff><wicri:noCountry code="subfield">BC V6T2B5 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington School of Medicine, Seattle, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neurobiology of Aging</title><idno type="ISSN">0197-4580</idno><idno type="eISSN">1558-1497</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Previous studies demonstrated decreased levels of DJ-1 and α-synuclein (αSYN) in human cerebrospinal fluid (CSF) in patients with Parkinson’s disease (PD), but neither marker correlated with PD severity, raising the possibility that they may be excellent progression markers during early or preclinical phases of PD. Individuals carrying the leucine-rich repeat kinase 2 (LRRK2) gene mutation are at increased risk for PD, and the phenotype of LRRK2 patients is almost identical to sporadic PD. To determine whether dopaminergic dysfunction in the basal ganglia, as determined by positron emission tomography (PET) scans, correlates with CSF levels of DJ-1 and αSYN during preclinical stages, Luminex assays were used to analyze CSF samples from asymptomatic LRRK2 mutation carriers, along with carriers who presented with a clinical diagnosis of PD. The data revealed no statistically significant relationship between PET scan evidence of loss of striatal dopaminergic function and the CSF biomarkers DJ-1 and αSYN, except for a weak correlation between DJ-1 and MP binding, suggesting that the use of these potential biomarkers on their own to screen LRRK2 gene mutation carriers for PD is not appropriate.</p></div></front></TEI><affiliations><list><country><li>Japon</li><li>Norvège</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Trøndelag</li></region><settlement><li>Trondheim</li></settlement></list><tree><noCountry><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Shi, Min" sort="Shi, Min" uniqKey="Shi M" first="Min" last="Shi">Min Shi</name></noRegion><name sortKey="Armaly, Jeff" sort="Armaly, Jeff" uniqKey="Armaly J" first="Jeff" last="Armaly">Jeff Armaly</name><name sortKey="Furay, Amy" sort="Furay, Amy" uniqKey="Furay A" first="Amy" last="Furay">Amy Furay</name><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name></country><country name="Norvège"><region name="Trøndelag"><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name></region></country><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Hasegawa, Kazuko" sort="Hasegawa, Kazuko" uniqKey="Hasegawa K" first="Kazuko" last="Hasegawa">Kazuko Hasegawa</name></noRegion><name sortKey="Yokoyama, Teruo" sort="Yokoyama, Teruo" uniqKey="Yokoyama T" first="Teruo" last="Yokoyama">Teruo Yokoyama</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001695 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001695 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3279603
|texte= DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22019052" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |